- Title
- Therapeutic potential of mitophagy-inducing microflora metabolite, urolithin a for alzheimer’s disease
- Creator
- Jayatunga, Dona Pamoda W.; Hone, Eugene; Khaira, Harjot; Lunelli, Taciana; Singh, Harjinder; Guillemin, Gilles J.; Fernando, Binosha; Garg, Manohar L.; Verdile, Giuseppe; Martins, Ralph N.
- Relation
- Nutrients Vol. 13, Issue 11, no. 3744
- Publisher Link
- http://dx.doi.org/10.3390/nu13113744
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Resource Type
- journal article
- Date
- 2021
- Description
- Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neuro-degenerative disorders including Alzheimer’s disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include investigating impaired mitochondrial pathways for potential therapeutic benefits against AD. Thus, a future therapy for AD may focus on novel candidates that enhance optimal mitochondrial integrity and turnover. Bi-oactive food components, known as nutraceuticals, may serve as such agents to combat AD. Uro-lithin A is an intestinal microbe-derived metabolite of a class of polyphenols, ellagitannins (ETs). Urolithin A is known to exert many health benefits. Its antioxidant, anti-inflammatory, anti-athero-genic, anti-Aβ, and pro-mitophagy properties are increasingly recognized. However, the underly-ing mechanisms of urolithin A in inducing mitophagy is poorly understood. This review discusses the mitophagy deficits in AD and examines potential molecular mechanisms of its activation. More-over, the current knowledge of urolithin A is discussed, focusing on its neuroprotective properties and its potential to induce mitophagy. Specifically, this review proposes potential mechanisms by which urolithin A may activate and promote mitophagy.
- Subject
- Alzheimer’s disease; mitophagy; neuroprotection; nutraceuticals; pomegranate; urolithin A
- Identifier
- http://hdl.handle.net/1959.13/1492931
- Identifier
- uon:53452
- Identifier
- ISSN:2072-6643
- Rights
- © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
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